The benefits of lyophilization



In comparison to conventional drying methods such as boiling drying, spray drying, and vacuum drying, freeze-drying offers the following notable advantages:

a. Lyophilization involves drying at low temperatures, which prevents protein denaturation while causing a loss of biological activity in microorganisms. This is particularly beneficial for the dry preservation of bioactive, biochemical, genetically engineered, and blood products that exhibit poor thermal stability.

b. The low-temperature drying process effectively inhibits microbial growth and enzymatic activity, thereby preserving the original properties of the material.

c. Freeze-drying maintains the original volume and shape of the material, resulting in a sponge-like texture with no shrinkage. The rehydrated product has a large contact surface with water and quickly regains its original shape.

d. The vacuum environment during the drying process minimizes oxygen presence, thus protecting easily oxidizable substances.

e. Freeze-drying can remove 95% to 99.5% of the water content in the substance, leading to a finished product with an extended shelf life.