The application of freeze-drying



Freeze-drying technology is gaining increasing popularity due to its unmatched advantages compared to other drying methods. It has found wide-ranging applications in various fields such as medicine, biological products, foodstuffs, and active substances. The scope of its applications continues to expand rapidly, and vacuum freeze drying is poised to become a crucial technology in the 21st century.

1. Application of freeze-drying technology in biological products:

a. Live bacterial vaccines: Examples include BCG, meningococcal vaccine, tuberculosis vaccine, oral live dysentery vaccine, Salmonella, Streptococcus, and more.

b. Viral vaccines: Such as measles vaccine, flu vaccine, rabies vaccine, chicken plague vaccine.

c. Other biological products and biochemical drugs: These encompass hepatitis B surface antigen diagnostic reagents, human leukocyte interferon, coenzyme A (CoA), adenosine triphosphate (ATP), urokinase, and others.

2. Application of freeze-drying technology in the production of Western medicine: Primarily utilized in the production of injectables, including antibiotics, cardiovascular drugs, central nervous system drugs, vitamins, and oncology drugs. Examples include ampicillin, erythromycin ethylsuccinate tablets, and more.

3. Application of freeze-drying technology in the production of traditional Chinese medicine: In recent years, there has been an increasing use of the freeze-drying method in processing proprietary Chinese medicines. This involves the steps of soaking, extraction, filtration, concentration, freeze-drying, and then transforming the resulting product into powder, tablets, or injections.

4. Medical applications: Freeze-drying technology is employed for the long-term preservation of various organs such as blood, arteries, bones, skin, cornea, and nerve tissue. When cells undergo lyophilization, they remain intact, allowing for revival upon rehydration. For instance, freeze-dried bones can be stored at room temperature or in a refrigerator for up to 2 years.

5. Freeze-drying in the food industry:

a. Cooking ingredients: Meat, eggs, fish, vegetables, and more.

b. Raw materials for the food industry: Milk powder, egg powder, vegetable protein powder, tea, dried fruit, meat meal, soybean meal, and similar products.

c. Beverages: Coffee, fruit drinks, and others.

d. Tonic categories: Pollen, honey powder, turtle powder, and similar items.

6.Other applications of freeze-drying technology:

a. Microbial and algae preservation: Long-term preservation of various bacteria, yeasts, enzymes, protozoa, microalgae, and more.

b. Biological specimens and tissue: Creation of diverse animal and plant specimens, dry preservation of skin, bones, aorta, heart valves, and other marginal tissues for animal xenotransplantation.

c. Preparation of small tissue sections for use in light microscopy, scanning electron microscopy, and transmission electron microscopy.

d. Food drying: Freeze-drying is utilized for coffee, tea, meat and fish products, seaweed, fruits, vegetables, spices, tofu, instant food, and similar items.

e. Advanced nutrition and Chinese herbal medicine: Examples include royal jelly, honey, pollen, and herbal preparations.

f. Ultrafine powder preparation: Freeze-drying is used for the production of ultrafine powders such as Al2O3, ZrO2, TiO2, Ba2Cu3O7~8, Ba2Ti9O20, and others.

g. Other applications include enhanced catalytic efficiency in the chemical industry through lyophilization of catalysts (increasing efficiency by 5 to 20 times), preservation of leaves and soil for studying the effects of soil, fertilizer, and climate on plant growth, and drying of damp wooden artifacts and submerged book articles using freeze-drying methods.